A question of payload

When driving north on I494 I passed a white and purple semi-trailer truck designed to carry livestock. Openings perforated the trailer and through the openings I could see the bare floor inside, strewn with hay. The trailer was empty of animals, but some had recently been there and others would soon fill it again. The door of the cab said “Livestock Transport.” This driver obviously specializes in this payload. I wonder if it feels different—maybe less lonely?—for a driver to drive mile after mile with a payload of breathing cows or horses or even turkeys behind him compared with boxes of electrical equipment or mattresses or lumber?